Nucleosomics: Accessing the Epigenome
NuQ® immunoassays: a range of nucleosome profiling kits based on Volition’s Nucleosomics® technology


Nucleosomics® - Accessing the Epigenome

Volition’s NuQ® range of research use only epigenetic research tools is available to life science researchers in a familiar and accessible format – the simple immunoassay.

Key features:

NuQ® assays are robust, reliable and reproducible.

No specialist equipment or training is required and simplicity of use and data interpretation is at the heart of our standard immunoassay format.

How it Works

Volition’s NuQ® range of products is based on the Nucleosomics® platform, which identifies and measures nucleosome structures in cell culture.

  • DNA is compacted as protein complexes in a “beads on a string” structure.
  • Nucleosome “beads” consist of DNA wrapped around a core of histone proteins.
  • Each core consists of four pairs of variants of H2A, H2B, H3 and H4 histones.
  • Histones and the DNA are subject to a variety of post translational modifications.
  • Various proteins interact with nucleosomes to modulate gene expression.
  • Each NuQ® ELISA captures intact nucleosomes and labels a specific feature.
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